NFL Sunday Computer Picks

Sunday's and the NFL go together like peanut butter and jelly. BetQL's NFL computer picks break down Sunday's biggest NFL games to give you the sweetest tips and predictions. We're your #1 source for the best NFL predictions all season long so make sure to check back every week for all the latest NFL computer picks.

Buffalo Bills (0-0) at Houston Texans (0-0)

We have trending betting tips for the upcoming game between the Houston Texans and the Buffalo Bills on Sunday, 13.09.2026, at the NRG Stadium. Kickoff is set for 1:00 PM, and the matchup promises to be an exciting one, fueled by the anticipation of new strategies and player performances as the season kicks off.

Houston Texans Overview

The Houston Texans, led by Coach DeMeco Ryans, are looking to make a strong impression in this season opener. Although they are starting from scratch in the league standings with no games played yet this season, the Texans had a solid end to the previous season. In their last five encounters, they demonstrated resilience despite facing tough competition:

• Texans 13 - Panthers 16 (Preseason, Loss)
• Texans 20 - Raiders 22 (Preseason, Loss)
• Texans 7 - Chargers 27 (Preseason, Loss)
• Texans 16 - Patriots 28 (Divisional Playoffs, Loss)
• Texans 30 - Steelers 6 (Wild Card Weekend, Win)

The Texans' key player to watch this season is their leading quarterback, whose performance last season was notable, making impactful plays that lifted the team during crucial moments. While we don't have individual personal statistics for this game yet, expectations are high for him to lead the Texans effectively.

Buffalo Bills Overview

On the other side, the Buffalo Bills, coached by Sean McDermott, come in with high expectations after a successful previous season. Like the Texans, they too are entering the season with no current standings but have recently proven their mettle on the field. The Bills have been formidable opponents in their last five games:

• Bills 28 - Steelers 27 (Preseason, Win)
• Bills 31 - Browns 7 (Preseason, Win)
• Bills 29 - Panthers 14 (Preseason, Win)
• Bills 30 - Broncos 33 (Divisional Playoffs, Loss)
• Bills 27 - Jaguars 24 (Wild Card Weekend, Win)

Key for the Bills this season will be their star quarterback, who showcases strong leadership and explosive passing abilities, making him a critical factor in their offensive strategy.

Head-to-Head Statistics

In past encounters between these two teams, the Texans and Bills have experienced a mixture of intense competition. The most recent results from their matchups have been closely contested, with points often being settled in single digits. This history adds an extra layer of excitement as both teams prepare to face off once more, especially with the following notable scores in their previous games.

Predictions for the Game

Our NFL prediction for this game suggests that the Texans will narrowly edge out the Bills in what could be a thrilling contest.

1. Moneyline prediction: Home win for Houston Texans at odds of -111 with Fanatics Sportsbook.
2. Best NFL point spread: Away win for Buffalo Bills (+1.5 points) at odds of -125 with Fanatics Sportsbook.
3. Points total betting market: Expecting an exciting run that goes over 43.5 total points, also at -125 odds with Fanatics Sportsbook.

Summary

The opening game of the season between the Houston Texans and the Buffalo Bills is set to be a highlight for fans. With both teams arriving with ambitions to start strong, and a range of predictions favoring close outcomes, this encounter promises to deliver. Expect high energy, strategic plays, and significant moments that could define the trajectory of both teams' seasons. Don't miss out on what looks to be a nail-biter!

Check out our full game analysis here

Chicago Bears (0-0) at Carolina Panthers (0-0)

We have trending betting tips for the exciting game between the Carolina Panthers and the Chicago Bears, set to take place on Sunday, September 13, 2026, at 1:00 PM. This highly anticipated contest will occur at the Bank of America Stadium, where fans will be eager to see which team will emerge victorious in this showdown.

Carolina Panthers Overview

The Carolina Panthers, led by head coach Dave Canales, are coming into this game looking to assert themselves in the new season. Although the Panthers have yet to play any games this season, their performance last year showed promise. Here are their last five games:

• January 10, 2026: Carolina Panthers 31 - 34 Los Angeles Rams
• August 6, 2026: Carolina Panthers 33 - 30 Arizona Cardinals
• August 15, 2026: Carolina Panthers 14 - 29 Buffalo Bills
• August 21, 2026: Carolina Panthers 34 - 17 Jacksonville Jaguars
• August 28, 2026: Carolina Panthers 16 - 13 Houston Texans

With a solid preseason, the Panthers are keen to capitalize on their momentum as they enter the new campaign.

Chicago Bears Overview

The Chicago Bears, coached by Ben Johnson, are also aiming to kick off their season with a strong performance. They too are looking to build on the experiences gathered from last season. Here are their last five games:

• January 18, 2026: Chicago Bears 17 - 20 Los Angeles Rams
• January 10, 2026: Chicago Bears 31 - 27 Green Bay Packers
• August 15, 2026: Chicago Bears 34 - 10 Cleveland Browns
• August 22, 2026: Chicago Bears 9 - 27 Cincinnati Bengals
• August 29, 2026: Chicago Bears 24 - 15 Tennessee Titans

The Bears are eager to showcase their skills right from the start and will be looking for a strong showing against the Panthers.

Head-to-Head Statistics

When examining the history between the two teams, the matchup has seen competitive battles. In their previous encounters, the statistics suggest a closely contested rivalry.

In their last games:

• Carolina Panthers 31 - 34 Chicago Bears
• Chicago Bears 17 - 20 Carolina Panthers

Predictions for the Game

Our NFL prediction is in favor of an away win for the Chicago Bears, with a moneyline set at -143 through BetMGM Sportsbook.
Best NFL point spread is also leaning towards an away victory for Chicago Bears at -2.5 points (-118 at BetMGM Sportsbook). Lastly, for those interested in the scoring expectations, the total points are set over 45.5 points with odds of -110 at BetMGM Sportsbook.

Summary

This game promises to be a thrilling start to the season, with both the Carolina Panthers and the Chicago Bears eager to prove their worth. With the away team favored to win, fans can expect an intense and exciting showdown. Don’t miss out on the action!

Click here for our full match analysis.

Cleveland Browns (0-0) at Jacksonville Jaguars (0-0)

We have trending betting tips for the exciting NFL game on Sunday, September 13, 2026, where the Jacksonville Jaguars will host the Cleveland Browns. This thrilling matchup is expected to take place at an undisclosed stadium, and it marks the opening week of the NFL season, with both teams eager to kick off their campaigns with a victory.

Jacksonville Jaguars Overview

The Jacksonville Jaguars, under the leadership of coach Liam Coen, are looking to start their season strong. In their last five games, they showcased a mix of performances during the preseason, including:

• Jaguars 19 - 0 Buccaneers
• Jaguars 17 - 34 Panthers
• Jaguars 24 - 20 Saints
• Jaguars 24 - 27 Bills (Wild Card Weekend)
• Jaguars 41 - 7 Titans

Although current statistics for individual players are unavailable, the team has shown resilience and potential in their recent performances. They will be looking to use the momentum from their preseason and prior playoff experience to establish dominance in this game.

Cleveland Browns Overview

On the other side, the Cleveland Browns, guided by coach Todd Monken, will be aiming to start their season on the right foot as well. Their last five games reveal some challenges faced during the preseason:

• Browns 37 - 13 Patriots
• Browns 7 - 31 Bills
• Browns 10 - 34 Bears
• Browns 20 - 18 Bengals
• Browns 13 - 6 Steelers

Despite some setbacks noted in the preseason, they demonstrated their capacity to pull through tight matches, especially against rivals like the Steelers. These lessons learned will be crucial as they head into their opening game.

Head-to-Head Statistics

When it comes to the head-to-head performance between these two teams, the competitiveness is apparent. In their recent encounters, the Jaguars and Browns have engaged in closely contested games. Their last results have shown:

• Jaguars 24 - 27 Browns
• Jaguars 28 - 21 Browns
• Jaguars 20 - 31 Browns

This history adds an intriguing layer to their upcoming matchup, as past results could influence players' motivation and strategies on the field.

Predictions for the Game

1. Moneyline Prediction: Our NFL prediction is a home win for the Jacksonville Jaguars at odds of -385 from Caesars Sportsbook.
2. Spread Prediction: The best NFL point spread is also favoring the Jaguars, with a -7.0 points spread available at -111 from Caesars Sportsbook.
3. Points Total Betting Market: Expect an exciting game with over 40.5 points projected at odds of -111 from Caesars Sportsbook.

In summary, this matchup between the Jacksonville Jaguars and the Cleveland Browns promises to be an explosive kick-off to the NFL season. With both teams looking to establish their identity early in the season, fans can expect a nail-biting performance on the field. The predictions lean towards the Jaguars, particularly considering their home advantage and recent form. Don't miss out on this thrilling game!

Click here for our full match breakdown.