NFL Week 1-17 Lines: Biggest Spreads, Highest Totals

The lines for Week 1 through 17 of this NFL season are out and there are some spreads and totals to highlight. There is also one team that's favored to win each of their games, as well as one that is the underdog in every one of their matchups. Here are some of the most notable betting odds for Week 1-17 of the 2021 NFL season. 

(Odds courtesy of BetMGM) 

The biggest spreads for matchups this season all involve the Houston Texans. The Buffalo Bills are -14 against the Texans in Week 4, the San Francisco 49ers are -13.5 against Houston in Week 17, and the Cleveland Browns are -13 against them in Week 2. 

As for the smallest spreads, the Arizona Cardinals are a pick’em vs. the 49ers in Week 5, the Carolina Panthers are a pick’em against the New England Patriots in Week 9, and the Pittsburgh Steelers are a pick’em against the Browns in Week 17. 

Check out all the latest sportsbook offers below!

The games with the highest totals all involve the Kansas City Chiefs. The total for their matchup against the Dallas Cowboys in Week 11 is 55, against the Bills in Week 5 it is 54.5, as it is for their Week 7 game against the Tennessee Titans. 

For the lowest, the total for the Chicago Bears-New York Giants Week 17 matchup is 42 points, the Denver Broncos matchup against the New York Jets in Week 3 has a total of 42.5 points, and the Baltimore Ravens meeting with the Los Angeles Rams Week 17 also has a total of 42.5.

The Chiefs, the favorites to win the Super Bowl at +450, are favored in every one of their games this season, while the Texans are the underdogs in each of their games. Houston has the longest odds to win the Super Bowl at +30000. 

Visit our NFL page for more information on this season and all of our Best Bets.