NFL Playbook: Betting Lines, Odds & Picks For Week 2

The NFL season moves into Week 2, and BetQL is your source for NFL best bets, live NFL public bets, live NFL sharp data, NFL line movement and historical betting trends in addition to our NFL articles that cover the sport from top to bottom. Scroll down to see all the best bets and key betting trends for this week's top matchups.

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MORE: SPORTSBOOKS’ BEST PROMOS FOR NFL WEEK 2

Chargers at Chiefs

ATS Record: Chargers 1-0, Chiefs 1-0

O/U Record: Chargers 0-1, Chiefs 1-0

The Chargers got their vengeance on the Raiders for last year’s Week 18 loss. But the NFL didn’t make things any easier on them in Week 2 by sending them to Kansas City in a short week. Oddly enough, the road team has won the last four games in this rivalry, which means the Chargers have won at Arrowhead in back-to-back seasons. However, the Chiefs were arguably the most impressive team in Week 1, thrashing the Cardinals 44-21. Plus, Kansas City is 24-7 SU in September and 41-12 SU against AFC West foes under Andy Reid.

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Jets at Browns

ATS Record: Jets 0-1, Browns 1-0

O/U Record: Jets 0-1, Browns 1-0

The Jets were outplayed by one AFC North team last week but will hope for better luck against another one this week. The problem is that with last week’s loss, the Jets have now lost their last 13 September games. The team’s last September win was Week 1 of the 2018 season. Of course, the Browns are far from perfect, as they led by 13 points heading into the fourth quarter last week and needed a 58-yard field goal in the closing seconds to win. Also, Jacoby Brissett averaged a paltry 4.3 yards per pass in Week 1, so the Cleveland offense looks a little limited in that area.

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Patriots at Steelers

ATS Record: Patriots 0-1, Steelers 1-0

O/U Record: Patriots 0-1, Steelers 0-1

It’s rare to see the Steelers listed as home underdogs, but that’s probably because they are the luckiest 1-0 team in the league. If the Bengals didn’t lose their long snapper to injury last week, Cincinnati probably finds a way to win that game despite the Steelers forcing five turnovers, including a pick-six. Even with 10 extra minutes in overtime and a last-second field goal to win, Mitch Trubisky and the Pittsburgh offense produced just 267 total yards, so there are problems on that side of the ball. Meanwhile, the Patriots had a rough Week 1 trip to Miami and now have to visit Pittsburgh. The silver lining is that Bill Belichick is 28-11 ATS in his career with the Patriots when coming off a loss of 10 points or more.

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Colts at Jaguars

ATS Record: Colts 0-1, Jaguars 0-1

O/U Record: Colts 0-1, Jaguars 1-0

Few teams should be as embarrassed as the Colts coming out of Week 1. They had high expectations for the season after acquiring Matt Ryan during the offseason, only to fall flat and tie the lowly Texans. While Indy came alive in the second half after a sluggish start, the Colts couldn’t find the winning score in overtime. While the Colts are understandably road favorites after the Jaguars blew an eight-point lead in the final 10 minutes of Week 1, that’s not necessarily good news for Indy. The home team has won the last nine games in this AFC South rivalry. In fact, the Colts haven’t won a game in Jacksonville since 2014 when Andrew Luck and Blake Bortles were the respective starting quarterbacks.

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Commanders at Lions

ATS Record: Commanders 1-0, Lions 1-0

O/U Record: Commanders 1-0, Lions 1-0

The Lions are actually favored in a game! While they came up a little short Week 1, it’s hard to fault Detroit’s effort. The Lions have also gone 10-3 ATS under Dan Campbell when playing on turf, as they’ve been tough at home. Remember the Lions won their last three home games of the 2021 season and had two other home losses by two points. On the other side, Carson Wentz threw four touchdown passes but also two interceptions in his debut with the Commanders, so there were surely some negative takeaways from Washington’s Week 1 victory.

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Dolphins at Ravens

ATS Record: Dolphins 1-0, Ravens 1-0

O/U Record: Dolphins 0-1, Ravens 0-1

Baltimore is already 1-0 against the AFC East this year, as the Ravens open the season with four straight games against that division. They’ll try to make it 2-0 in their home opener while avenging a 22-10 loss in Miami last November. Despite a convincing, 24-9, win over the Jets last week, the Ravens were out-gained 378 to 274. However, that could be good news, as John Harbaugh is 27-9 SU immediately after a game in which Baltimore is out-gained by at least 100 yards. Also, the Dolphins have been outscored 78-6 in their last two trips to Baltimore in 2016 and 2017. In fact, Miami hasn't had a road win over the Ravens since the first all-time meeting between these teams in 1997.

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Buccaneers at Saints

ATS Record: Buccaneers 1-0, Saints 0-1

O/U Record: Buccaneers 0-1, Saints 1-0

The Saints should count their lucky stars that they managed to come from behind to beat the Falcons, 27-26, last week despite failing to cover the spread as road favorites. The problem New Orleans now faces is that Dennis Allen is 1-9 ATS as a head coach immediately after a game in which 50 or more points were scored. On the bright side, the Saints have won the last seven regular-season meetings between these two teams. They are also 9-3 SU in their last 12 home games against the Bucs, although one of those losses came in the playoffs two seasons ago when the Bucs went on to win the Super Bowl. 

Panthers at Giants

ATS Record: Panthers 0-1, Giants 1-0

O/U Record: Panthers 1-0, Giants 0-1

After pulling off a shocking road win in Week 1 at Tennessee, the Giants are now home favorites in Week 2. Obviously, the G-Men are far from perfect, but it certainly doesn’t hurt that they took care of business against Carolina last year, winning 25-3 at MetLife Stadium. The Panthers, to their credit, overcame a 13-point deficit in the fourth quarter last week against Cleveland, only to lose the game on a late, 58-yard field goal. But they were also out-gained at home by nearly 100 yards with Christian McCaffrey held to just 57 total yards on 14 touches, which isn’t going to be enough most weeks.

Seahawks at 49ers

ATS Record: Seahawks 1-0, 49ers 0-1

O/U Record: Seahawks 0-1, 49ers 0-1

The Seahawks finished a week of surprising results with an upset of the Broncos on Monday night. That shouldn’t have been too much of a surprise, as Pete Carroll is 51-29 ATS as an underdog during his time in Seattle. Carroll will put that record to the test again in Week 2, as the 49ers are 9.5-point home favorites despite laying an egg against the Bears in Week 1. To be fair, the San Francisco defense played well enough to win, as the 49ers didn’t get enough from Trey Lance and the offense. Meanwhile, it’s worth noting that Kyle Shanahan is just 2-8 SU against the Seahawks as San Francisco’s head coach. While this isn’t the same Seattle team as a few years ago, the Seahawks have still won seven of their last eight road games against the 49ers.

Falcons at Rams

ATS Record: Falcons 1-0, Rams 0-1

O/U Record: Falcons 1-0, Rams 0-1

A poor performance in Week 1 by the Super Bowl champions hasn’t stopped the oddsmakers from making the Rams double-digit home favorites in Week 2. On the other side, the Falcons have to be just as disappointed, as they let a 26-10 fourth-quarter lead slip away from them. The silver lining for Atlanta is the Falcons have won five of the last six and seven of the last nine head-to-head meetings with the Rams, including a playoff game in Los Angeles after the 2017 season. But most of those games were before Sean McVay took over in L.A. McVay entered this season 9-1 SU during the first two weeks of the season and 28-9 SU during the first half of the season, so two losses this early in the season would be unusual.

Bengals at Cowboys

ATS Record: Bengals 0-1, Cowboys 0-1 

O/U Record: Bengals 0-1, Cowboys 0-1

It’s hard to decide what team is in more trouble. The Bengals lost at home in Week 1 after turning it over five times. To be fair, Cincinnati probably survives with a win if the team’s long snapper didn’t get hurt. Meanwhile, the Cowboys lost 19-3 at home in Week 1 and lost Dak Prescott to injury for at least a month. Plus, both teams are the only team in their division to lose in Week 1. A potential shootout could favor the Cowboys, who are 6-0 ATS over the last two years when the over/under is between 42.5 and 49 points.

Cardinals at Raiders

ATS Record: Cardinals 0-1, Raiders 0-1

O/U Record: Cardinals 1-0, Raiders 0-1

Both of these teams made the playoffs last season, but one of them is going to fall into a 0-2 hole to open the 2022 campaign. Playing at home didn’t help the Cardinals last week, so maybe a road trip to Vegas will. Under Kliff Kingsbury, the Cardinals have gone 17-8 ATS on the road and 18-9 ATS as underdogs. In fact, Kingsbury is 14-12 SU when his team is an underdog during his NFL career.

Texans at Broncos

ATS Record: Texans 1-0, Broncos 0-1

O/U Record: Texans 0-1, Broncos 0-1

The red zone turned out to be Denver’s Kryptonite in Week 1, spoiling Russell Wilson’s debut with his new team. There were also some questionable coaching decisions that led to the Broncos scoring just 16 points despite Wilson throwing for 340 yards. Despite the disappointment, the Broncos are still 10-point favorites in Week 2 for their home opener. While the Texans pulled off a stunning tie with the Colts, they led 20-3 heading into the fourth quarter and blew the lead. They were also out-gained by more than 200 yards against the Colts, so there are plenty of reasons for Houston to still be concerned. 

Bears at Packers

ATS Record: Bears 1-0, Packers 0-1

O/U Record: Bears 0-1, Packers 0-1

The Bears were surprising winners at home against the 49ers in Week 1, while the Packers put together a truly dreadful performance in their 23-7 loss to the Vikings. But that isn’t stopping the oddsmakers from making Green Bay a double-digit favorite at home. If you remember, the Packers lost 38-3 in Week 1 last year but quickly bounced back with seven consecutive wins, four of which came by 10 points or more. Also, the Packers have swept the season series from the Bears in three straight seasons, including a pair of wins by 10 points or more last year. In fact, the Bears haven’t won a game at Lambeau Field since Thanksgiving 2015.

Titans at Bills

ATS Record: Titans 0-1, Bills 1-0

O/U Record: Titans 0-1, Bills 0-1

A little slip by Josh Allen at the goal line last year cost the Bills in a Monday night game against the Titans. Buffalo will look for redemption this year in the team’s home opener in what could be the most anticipated season the Bills have had in decades. Expectations surely won’t be tempered much after a dominant Week 1 that saw Buffalo out-gain the reigning champion Rams 413 to 243. Under Sean McDermott, the Bills are 16-6 SU following a game in which they out-gained their opponent by at least 100 yards. They will try to improve that record against a Tennessee team that is feeling the embarrassment of a home loss to the Giants last week.

Vikings at Eagles

ATS Record: Vikings 1-0, Eagles 0-1

O/U Record: Vikings 0-1, Eagles 1-0

While the Eagles didn’t cover the spread in Week 1, both of these teams had impressive victories last week. The Vikings couldn’t have looked much better in their win over the Packers while the Eagles were able to hold off the Lions on the road. Philadelphia’s offense looked balanced last week with A.J. Brown making an immediate impact with 10 catches for 155 yards. But the Eagles went just 3-5 SU at home last year, which is something they’ll have to rectify this year if they hope to live up to their potential. Likewise, the Vikings were just 3-6 SU on the road in 2021, which is an issue they need to correct in 2022.

MORE: SPORTSBOOKS’ BEST PROMOS FOR NFL WEEK 2

BetQL subscribers get more betting trends and all of our best bets, including player props, with star ratings for every pick. Take advantage of BetQL's free trial and see all of this week's best NFL bets, plus what the model is projecting for every college football game! Start your free trial today!