NFL Betting Guide: Lines, Odds & Picks For Week 10

NFL Betting Lines, Odds & Picks For Week 10

The NFL season moves into Week 10, and BetQL is your source for NFL best bets, live NFL public bets, live NFL sharp data, NFL line movement and historical betting trends in addition to our NFL articles that cover the sport from top to bottom. Scroll down to see all the best bets and key betting trends for this week's top matchups.

Speaking of trends, the BetQL NFL model is on a roll, going 14-5 (74%) on all picks rated ⭐⭐⭐⭐ and higher last week! BetQL subscribers can see more betting trends and all of our best bets, including player props, with star ratings for every pick. Take advantage of BetQL's free trial and see all of this week's best NFL bets, plus what the model is projecting for every college football game! Start your free trial today!

MORE NFL WEEK 10: BETQL EDITORS’ PICKS | TOP NFL PLAYER PROPS

Falcons at Panthers

ATS Record: Falcons 6-3, Panthers 3-6

O/U Record: Falcons 5-4, Panthers 4-5

Thursday’s game doesn’t have a team with a winning record but it does have an overlooked rivalry. The Falcons are aiming for the season sweep of Carolina and their fifth straight road win against the Panthers, who haven’t held serve at home against Atlanta since 2017. Remember, these teams met just two weeks ago in that wild, 37-34, overtime win for the Falcons. Of course, Carolina did beat the spread in that game as Atlanta has now lost three in a row ATS after starting the year 6-0 ATS. But watch the odds closely between now and Thursday because the Falcons are 6-0 SU over the last two years while on the road with a moneyline between -150 and +130. They are also 6-0 ATS on the road over the last two years when the spread is between -3 and +3.

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Seahawks at Buccaneers

ATS Record: Seahawks 6-3, Buccaneers 2-6-1

O/U Record: Seahawks 5-4, Buccaneers 2-7

These teams have essentially switched positions from where most expected them to be this season. Yet, the Bucs are still favorites in this game in Germany after snapping a three-game losing streak with a win over the Rams last week. Of course, the Seahawks clearly have no problem being an underdog. They’ve won four in a row, including three games in which they’ve been an underdog, making them 5-2 SU in an underdog role.

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Vikings at Bills

ATS Record: Vikings 3-4-1, Bills 4-3-1

O/U Record: Vikings 4-4, Bills 1-7

With the Vikings continuing to stay hot, this might be the most intriguing game of the weekend. However, this is only the second time the Vikings have been an underdog this season, and they lost the other game to the Eagles. In fact, Minnesota is 0-2-1 on the road. Meanwhile, the Bills are hoping to bounce back from a disappointing loss to the Jets last week. Under Sean McDermott, Buffalo is 10-2 SU following a loss by three points or less. They’ve also won all three of their home games by at least 10 points. However, Josh Allen’s elbow injury is something to monitor during the week.

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Broncos at Titans

ATS Record: Broncos 3-5, Titans 6-2

O/U Record: Broncos 1-7, Titans 2-6

Even after failing to hold onto their lead against the Chiefs last week, the Titans are trending in the right direction. Of course, while they don’t have an ATS loss since Week 2, the Titans have scored fewer than 20 points in three straight weeks. Even before Ryan Tannehill got hurt, the Tennessee offense was struggling. The Broncos are in a similar position, playing outstanding defense all season but scoring more than 16 points just twice in eight games. They are also 3-2 ATS as an underdog this season.

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Lions at Bears

ATS Record: Lions 4-4, Bears 4-4-1

O/U Record: Lions 5-3, Bears 5-4

The Bears haven’t been particularly good in recent years, although they are 7-1 against the Lions over the last four seasons. That makes Chicago a reasonable home favorite, especially since the Bears won the only other game this year in which they were favored. Of course, the Lions are coming off an actual win over the Packers, giving up just nine points despite allowing a league-high 29.3 points per game. However, they’ve lost their last two road games by a combined score of 53-6.

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Jaguars at Chiefs

ATS Record: Jaguars 3-6, Chiefs 3-5

O/U Record: Jaguars 4-5, Chiefs 4-4

After their comeback win over the Titans last week, the Chiefs are clearly among the elite teams in the AFC. However, they are just 1-4 ATS in games that they’re favored in this season. They’re also 0-4 ATS when playing at home. They’ll try to change that trend this week against a Jacksonville team that won last week to snap a five-game losing streak. Despite being 3-6 on the season, Jacksonville’s six losses have come by an average of 6.3 points with the Jaguars never losing a game by more than eight points, so they’ve always been competitive, even in their losses.

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Browns at Dolphins

ATS Record: Browns 4-4, Dolphins 4-5

O/U Record: Browns 5-2-1, Dolphins 5-4

Miami has started to turn things around with the return of Tua Tagovailoa, winning three in a row. However, they’ve lost six in a row ATS, so the Dolphins may not be the best favorite to back despite being 9-4 SU at home over the last two years. Meanwhile, the Browns had a bye week to enjoy their 32-13 win over the Bengals, although they are still desperate for wins if they want to have any chance of getting to the playoffs. The good news for Cleveland is they are 3-1 ATS as an underdog this year.

Texans at Giants

ATS Record: Texans 4-3-1, Giants 6-2

O/U Record: Texans 4-4, Giants 2-6

This is only the sixth all-time meeting between these franchises with the Texans winning the first but the G-Men taking the last four. The Giants are hoping to bounce back after having a bye week following their loss to the Seahawks. But keep in mind the G-Men are 3-1 at home and their only losses this season are against teams that are a combined 12-5. Yet, this is still just the third time they’ve been favored in 2022 and by far the greatest margin in which they’ve been favored. As for the Texans, they’ve been an underdog in every game this year. However, they are 4-1 ATS when the spread is seven points or more, so keep an eye on the spread to see if it increases to a touchdown or more during the week.

Saints at Steelers

ATS Record: Saints 3-6, Steelers 3-4-1

O/U Record: Saints 5-4, Steelers 3-5

Despite losing three of their last four games and playing in a short week, the Saints are road favorites in this game. They’ve been favored three other times this season but only won one of those games. Of course, the Steelers are in even worse shape but are hoping to turn things around after a bye. However, the Steelers haven’t scored more than 20 points since Week 1 and they have given up at least 35 points in two of their last four games, including their most recent game. The good news is Mike Tomlin is 12-3 ATS after the Steelers give up 35 points.

Colts at Raiders

ATS Record: Colts 3-6, Raiders 3-5

O/U Record: Colts 1-8, Raiders 4-4

After three straight losses, the Colts have fired Frank Reich, so perhaps that will do the trick because Indy’s other personnel moves haven’t turned things around for them. For what it’s worth, two of their three wins this year have come as underdogs and against other AFC West teams. Likewise, the Raiders have lost their last two games despite being a favorite in both. Las Vegas is just 2-4 SU and 2-4 ATS as a favorite this season. The good news is the Raiders are 2-1 SU at home.

Cowboys at Packers

ATS Record: Cowboys 6-2, Packers 3-6

O/U Record: Cowboys 2-5-1, Packers 3-6

This is typically a highly-anticipated rivalry game, although the luster is a little off with the Packers losing five in a row. Yes, the team with two-time reigning MVP Aaron Rodgers has lost five straight games, including last week’s pitiful, 15-9 loss to the Lions. But there are some trends working in Green Bay’s favor. For starters, the Packers have won eight of their last nine games against the Cowboys, including four of their last five home games against Dallas. The Packers are also 2-1 ATS as an underdog this year. However, the Cowboys are coming off a bye and 3-0 SU and 3-0 ATS when favored this season. Also, over the last two years, Dallas is 8-0 ATS when facing a team with a losing record.

Cardinals at Rams

ATS Record: Cardinals 4-5, Rams 2-5-1

O/U Record: Cardinals 4-5, Rams 3-5

Instead of competing for a playoff spot, these teams are just trying to stay out of the NFC West basement with the loser of this game destined to be last in the division after 10 weeks. The Rams might be 0-2 since their bye week but they’ve dominated the Cardinals in recent years, winning 11 of the last 12 meetings, including a 20-12 win earlier this season. Los Angeles is also 10-3 ATS under Sean McVay whenever they’ve lost two of their last three games. Meanwhile, the only silver lining for the Cardinals is that two of their three wins this season have come as a road underdog.

Chargers at 49ers

ATS Record: Chargers 5-3, 49ers 4-4

O/U Record: Chargers 4-4, 49ers 3-5

While these teams have only met once every four years over the last 20 years, the Chargers have won five in a row against the 'Niners. During the current campaign, the Chargers are 4-0 ATS on the road, going 3-1 SU away from home. In fairness, the Chiefs have been the only team to beat the 49ers at Levi’s Stadium this year. However, San Francisco is already 0-2 against the AFC West and just 3-3 SU as a favorite.

Commanders at Eagles

ATS Record: Commanders 4-4-1, Eagles 5-3

O/U Record: Commanders 3-6, Eagles 4-3-1

While the Eagles didn’t cover the spread in last week’s win, they remain a perfect 8-0 SU on the season. They also had no problem covering the 5.5-point spread when they won in Washington, 24-8, earlier this season. Philadelphia is now trying to complete a season sweep of Washington for the fifth time in the last six years. To be fair, the Commanders had won three in a row before last week’s 20-17 loss to the 7-1 Vikings. However, Ron Rivera is 0-9 ATS during his coaching career when coming off a home loss of three points or fewer. That’ll make bouncing back against the unbeaten Eagles even more difficult.

MORE: SPORTSBOOKS’ BEST PROMOS FOR NFL WEEK 10

BetQL subscribers get more betting trends and all of our best bets, including player props, with star ratings for every pick. Take advantage of BetQL's free trial and see all of this week's best NFL bets, plus what the model is projecting for every NBA, NHL, college football and college basketball game! Start your free trial today!