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San Francisco 49ers vsLos Angeles Rams Prediction

The Los Angeles Rams are a solid favorite with a 72% chance to beat the San Francisco 49ers. Darrell Henderson Jr. is projected for 36 rushing yards and a 34% chance of having at least 1 rushing TD. In the 28% of simulations where San Francisco 49ers wins, Nick Mullens averages 1.24 TD passes vs 0.67 interceptions, while in losses he has a ratio of 0.92 TDs to 1.37 interceptions. Raheem Mostert averages 63 rushing yards and 0.74 rushing TDs when San Francisco 49ers wins and 42 yards and 0.36 TDs in losses. The Los Angeles Rams has a 54% chance of forcing more turnovers than they commit. Positive turnover margin helps them win 87% of the time.

San Francisco 49ers vs Los Angeles Rams Prediction

The San Francisco 49ers are facing a must-win game in Week 12 as they travel to the south part of the state to take on the Los Angeles Rams. Kickoff is scheduled for 4:05 EST on Sunday, November 29, at SoFi Stadium in Inglewood, California. The Rams are currently favored by 7.5 points with the over/under set at 46.5 points. Keep reading to take a closer look at both teams and learn our model’s Rams vs 49ers prediction against the spread.

Los Angeles Rams Preview

It’s a short week for the Rams, but they’ll likely be feeling good after Monday’s win over the Buccaneers. Back-to-back wins over Seattle and Tampa Bay have surely made a statement to the rest of the NFC that Los Angeles is a contender. Equally important, those wins have put the Rams into a tie with the Seahawks for first place in the NFC West at 7-3. Of course, there’s a lot of football left to be played in the NFC West. In fact, the Rams play four of their final six games against divisional foes, including two games with the upstart Cardinals.

While he can be rough around the edges at times, L.A. quarterback Jared Goff is playing some of his best football of the past two years. Without much help from his running game on Monday, Goff threw for 376 yards and three touchdowns. In fairness, he also threw two interceptions, giving him eight picks in 10 games this year. But it was also Goff’s second straight game with over 300 passing yards against a top-flight NFC opponent, which bodes well for him and the L.A. offense moving forward, especially if the Rams can get their rushing attack back on track.

Defensively, the Rams have to be pleased with where they sit right now. On Monday, they limited Tom Brady and the Bucs to just 251 total yards, picking off Brady twice despite registering just one sack. To date, the Rams have allowed the second-fewest points in the NFL and are averaging over three sacks per game. More importantly, they are relatively healthy on defense, which has helped them maintain a high level of play on that side of the ball.

San Francisco 49ers Preview

It’s now or never for the reigning NFC champs, who were nursing a three-game losing streak before a much-needed bye last week. The 49ers come out of their bye at 4-6, putting them last in the NFC West and two games out of a wild-card spot. To make matters worse, San Francisco has one game left against each of the teams ahead of them in the NFC West. If the 49ers have a late playoff push in them, they’ll have to do it the hard way.

As Jimmy Garoppolo continues to nurse his second high-ankle sprain of the season, Nick Mullens continues to serve as the San Francisco starting quarterback. Mullens isn’t flashy or good enough to be a regular starter, but he’s surely a capable backup. The problem for the 49ers is that injuries have ravaged their backfield and the rest of their offense. Right now, the 49ers can’t provide Mullens with enough help because their offensive line is hurting and unable to create enough of a rushing attack to take the heat off the quarterback.

Unfortunately for the 49ers, it’s been a similar story on defense, as one key player after another has been placed on IR or suffered a serious injury. The result is a defense that’s giving up close to 33 points per game in its last three games. The only silver lining is that San Francisco held the Rams to just 16 points when the teams met earlier this year. But replicating that kind of performance could be difficult.

Full Game Prediction

The 49ers are facing an uphill battle against the Rams this week. Keep in mind that Garoppolo played one of his best games of the season against the Rams in a 24-16 win in October. San Francisco was able to win the battle at the line of scrimmage in this game, which won’t be easy to do this time around.

Don’t forget to sign up for a BetQL subscription that will give you access to important stats and analytics for this matchup and every other NFL game. You will also be able to see our model’s 49ers vs Rams prediction against the spread.

Bryan Zarpentine
Prediction Written by
Bryan Zarpentine

Bryan Zarpentine is a freelance writer and editor who specializes in sports and sports betting. Over the years, he has covered the NFL, MLB, college football, college basketball, and international and club soccer. Bryan is a graduate of Syracuse University and a lifelong fan of the Orange, as well as the New York Mets, Denver Broncos, and Tottenham Hotspur. When he’s not watching sports, there’s nothing he loves more than writing about sports, especially taking on unpopular opinions.

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