The Colts are coming off of the biggest upset of Week 3 after a 20-17 win over the Chiefs, while the Titans came through with their own must-win, 24-22 over the Raiders.
The Titans were the winner of the "Underachiever Bowl" in Week 3 over the Raiders, avoiding an 0-3 start, but things are obviously still pretty shaky in Tennessee.
They held the Raiders to just one third down conversion on 12 attempts, which obviously is a positive, but the offense couldn't get more than 85 yards rushing or receiving from anyone when it was all said and done.
Mike Vrabel is 7 - 1 straight up after allowing 375 or more total yards in two consecutive games while coaching Tennessee, with the Raiders having put up 396 total yards this past Sunday.
The Colts win over the Chiefs is a great example of the unpredictability if this NFL season. Opening as a seven-point favorite, Indy ended up covering +5.5, turning around what was turning into a disaster of a season.
Matt Ryan completed 27 of his 37 passes for 222 yards and two touchdowns, but Jonathan Taylor had just 71 yards rushing on 21 attempts. The Colts allow just 77.0 rushing yards per game, which puts them third in the NFL, and you can bet they'll do whatever they can to keep Taylor out of the game.
Something that's also worth keeping in mind: Frank Reich is 11 - 3 ATS after failing to cover the spread in two out of his last three games while coaching Indianapolis. His teams tend to start off slow, while turning things around as the schedule progresses.
After a big win over the Chiefs, that momentum can carry over into a game against a still very much underachieving Titans team. The Colts started off 0-3 last year, and yes it was with a different quarterback, but the confidence builder of their Week 3 win can work right into the pattern of Reich's teams of the past, setting them up for a 2-2 start after this weekend. Give me Colts -3.